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Florian Clemente Florian

Email: fjc31@cam.ac.uk

After my studies of bioinformatics in Munich, I received my Ph.D. degree in population genetics in Vienna. 


In general, my research interests are focused on forces driving evolution on the molecular level. I am particularly interested in the relative roles of genetic drift and natural selection in the process of adaptation to different environments.
Former projects:

During my Ph.D., I studied genome-wide putatively selectively unconstrained DNA sequences in Drosophila, i.e., short introns and fourfold degenerate sites. Unconstrained sequences are of importance to infer selection in another sequence class, but also to reconstruct the demographic history of a population. Our results showed that in Drosophila, short introns may in fact evolve without selective constraints, but underlie a complicated mutational pattern, creating non-equilibrium. Fourfold degenerate sites, on the other hand, are governed by more complex selectional forces than typically assumed in the biallelic model of codon usage bias.

Current project:
The large amount of newly sequenced world-wide human genomes allows the study of human adaptation to different environments and life styles. For instance, Northeast Siberians are exposed to extremely cold temperatures and a resulting high-fat diet. Thus they provide a unique and interesting case in the study of adaptation. Our projects involve the detection of (unique) candidate regions, presumably driven by positive selection in the population of interest. Candidate regions are then inspected in more detail, trying to distinguish between patterns created by genetic drift and natural selection.

 

 

 


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